Feasibility study of MEMS-based stenosis detection using a prototypical catheter design with intravascular scanning probes (IVSPs).

X-ray coronary angiography (XRA) is a standard clinical method for diagnosing coronary artery disease (CAD). However, despite continuous improvements in XRA technology, it has limitations that include being visible only in color contrast, and the information it provides on coronary artery plaques is not comprehensive due to its low signal-to-noise ratio and limited resolution. In this study, we propose a novel diagnostic tool, a MEMS-based smart catheter with an intravascular scanning probe (IVSP), to complement XRA and verify its effectiveness and feasibility. The IVSP catheter uses Pt strain gauges embedded on the probe to examine the characteristics of a blood vessel, such as the degree of stenosis and morphological structures of the vessel walls, through physical contact. The feasibility test results showed that the output signals of the IVSP catheter reflected the morphological structure of the phantom glass vessel that mimicked stenosis. In particular, the IVSP catheter successfully assessed the morphology of the stenosis, which was only 17% of the cross-sectional diameter obstructed. In addition, the strain distribution on the probe surface was studied using finite element analysis (FEA), and a correlation between the experimental and FEA results was derived.

Intensified recovery of switchable hydrophilicity solvents in flow.

We present an integrated flow chemistry strategy using two membrane-based flow reactors to enhance the extraction and recovery rates of switchable hydrophilicity solvents (SHSs) by five times compared to batch reactors. The developed green flow chemistry strategy achieves an overall single-pass recovery efficiency of 60.1% for 2-(dibutyl amino)ethanol.

A Versatile Compact Parahydrogen Membrane Reactor.

We introduce a Spin Transfer Automated Reactor (STAR) that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the PHIP variant called signal amplification by reversible exchange (SABRE), which is particularly well suited to produce continuous hyperpolarization. The STAR is operated in conjunction with benchtop (1.1 T) and high field (9.4 T) NMR magnets, highlighting the versatility of this system to operate with any NMR or MRI system. The STAR uses semipermeable membranes to efficiently deliver parahydrogen into solutions at nano to milli Tesla fields, which enables 1 H, 13 C, and 15 N hyperpolarization on a large range of substrates including drugs and metabolites. The unique features of the STAR are leveraged for important applications, including continuous hyperpolarization of metabolites, desirable for examining steady-state metabolism in vivo, as well as for continuous RASER signals suitable for the investigation of new physics.

Accelerating gas-liquid chemical reactions in flow.

Over the past decade, continuous flow reactors have emerged as a powerful tool for accelerated fundamental and applied studies of gas-liquid reactions, offering facile gas delivery and process intensification. In particular, unique features of highly gas-permeable tubular membranes in flow reactors (i.e., tube-in-tube flow reactor configuration) have been exploited as (i) an efficient analytic tool for gas-liquid solubility and diffusivity measurements and (ii) reliable gas delivery/generation strategy, providing versatile adaptability for a wide range of gas-liquid processes. The tube-in-tube flow reactors have been successfully adopted for rapid exploration of a wide range of gas-liquid reactions (e.g., amination, carboxylation, carbonylation, hydrogenation, ethylenation, oxygenation) using gaseous species both as the reactant and the product, safely handling toxic and flammable gases or unstable intermediate compounds. In this highlight, we present an overview of recent developments in the utilization of such intensified flow reactors within modular flow chemistry platforms for different gas-liquid processes involving carbon dioxide, oxygen, and other gases. We provide a detailed step-by-step guideline for robust assembly and safe operation of tube-in-tube flow reactors. We also discuss the current challenges and potential future directions for further development and utilization of tubular membrane-based flow reactors for gas-liquid processes.

Artificial Chemist: An Autonomous Quantum Dot Synthesis Bot.

The optimal synthesis of advanced nanomaterials with numerous reaction parameters, stages, and routes, poses one of the most complex challenges of modern colloidal science, and current strategies often fail to meet the demands of these combinatorially large systems. In response, an Artificial Chemist is presented: the integration of machine-learning-based experiment selection and high-efficiency autonomous flow chemistry. With the self-driving Artificial Chemist, made-to-measure inorganic perovskite quantum dots (QDs) in flow are autonomously synthesized, and their quantum yield and composition polydispersity at target bandgaps, spanning 1.9 to 2.9 eV, are simultaneously tuned. Utilizing the Artificial Chemist, eleven precision-tailored QD synthesis compositions are obtained without any prior knowledge, within 30 h, using less than 210 mL of total starting QD solutions, and without user selection of experiments. Using the knowledge generated from these studies, the Artificial Chemist is pre-trained to use a new batch of precursors and further accelerate the synthetic path discovery of QD compositions, by at least twofold. The knowledge-transfer strategy further enhances the optoelectronic properties of the in-flow synthesized QDs (within the same resources as the no-prior-knowledge experiments) and mitigates the issues of batch-to-batch precursor variability, resulting in QDs averaging within 1 meV from their target peak emission energy.

Leak Detection and Location of Water Pipes Using Vibration Sensors and Modified ML Prefilter.

This paper proposes a new leak detection and location method based on vibration sensors and generalised cross-correlation techniques. Considering the estimation errors of the power spectral densities (PSDs) and the cross-spectral density (CSD), the proposed method employs a modified maximum-likelihood (ML) prefilter with a regularisation factor. We derive a theoretical variance of the time difference estimation error through summation in the discrete-frequency domain, and find the optimal regularisation factor that minimises the theoretical variance in practical water pipe channels. The proposed method is compared with conventional correlation-based techniques via numerical simulations using a water pipe channel model, and it is shown through field measurement that the proposed modified ML prefilter outperforms conventional prefilters for the generalised cross-correlation. In addition, we provide a formula to calculate the leak location using the time difference estimate when different types of pipes are connected.

Expressional Changes of Water Transport-related Molecules in the Efferent Ductules and Initial Segment of Mouse Treated with Bisphenol A-Containing Drinking Water for Two Generations.

Bisphenol A (BPA) is an estrogenic endocrine disrupter. However, depending on a way of treatment, the harmful effects of BPA have not been confirmed. Also, trans-generational effects of BPA on male reproduction are still controversial. Because the reabsorption of testicular fluid in the efferent ductules (ED) and initial segment (IS) is important for sperm maturation, the present study was designed to determine trans-generational effect of BPA administrated orally on expression of water transport-related molecules in the mouse ED and IS. Ethanol-dissolved BPA was diluted in water to be 100 ng (low), 10 µg (medium), and 1 mg/Ml water (high). BPA-containing water was provided for two generations. Expression of ion transporters and water channels in the ED and IS were measured by relative real-time PCR analysis. In the ED, BPA treatment caused expressional increases of carbonic anhydrase II, cystic fibrosis transmembrane regulator, Na(+)/K(+) ATPase α1 subunit, and aquaporin (AQP) 1. No change of Na(+)/H(+) exchange (NHE) 3 expression was detected. BPA treatment at medium dose resulted in an increase of AQP9 expression. In the IS, the highest expressional levels of all molecules tested were observed in medium-dose BPA treatment. Generally, high-dose BPA treatment resulted in a decrease or no change of gene expression. Fluctuation of NHE3 gene expression by BPA treatment at different concentrations was detected. These findings suggest that trans-generational exposure to BPA, even at low dose, could affect gene expression of water-transport related molecules. However, such effects of BPA would be differentially occurred in the ED and IS.